|
Effects of anti-TWEAK and anti-TNF monoclonal antibodies on the secretion of IL-8, PGE2 and MMP-1 by synoviocytes stimulated by hTWEAK or TNF |
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| Stimulus |
None |
BCB10 (10 μg/ml) |
BEB3 (10 μg/ml) |
Anti-TNF (10 μg/ml) |
|
|
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| IL-8 secretion (ng/ml) |
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| None |
55.2 ± 3.1 |
38 ± 1.2 |
117.6 ± 18 |
49 ± 14 |
| hTWEAK |
146.4 ± 17 |
73 ± 19 |
277.2 ± 40 |
113.8 ± 7.3 |
| TNF |
232.6 ± 26 |
245 ± 33 |
nd |
44.7 ± 4.8 |
| MMP-1 secretion (ng/ml) |
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| None |
4248 ± 276 |
3848 ± 371 |
5383 ± 274 |
3482 ± 584 |
| hTWEAK |
6033 ± 773 |
4381 ± 22 |
7923 ± 1698 |
4878 ± 100 |
| TNF |
6197 ± 210 |
7846 ± 713 |
nd |
3505 ± 101 |
| PGE2 secretion (ng/ml) |
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| None |
50 ± 12 |
61 ± 6 |
81 ± 13 |
47 ± 13 |
| HTWEAK |
94 ± 7 |
87 ± 26 |
161 ± 30 |
78 ± 3 |
| TNF |
231 ± 49 |
471 ± 79 |
nd |
53 ± 5 |
| RANTES secretion (ng/ml) |
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| None |
0.12 |
0.23 |
0.23 |
0.05 |
| hTWEAK |
30.78 |
0.26 |
20.12 |
26.01 |
| TNF |
2.19 |
1.17 |
nd |
0.05 |
| IP-10 secretion (pg/ml) |
||||
| None |
274 |
386 ± 17 |
349 |
117 ± 84 |
| hTWEAK |
5095 ± 766 |
330 ± 140 |
3158 |
3735 ± 60 |
| TNF |
1710 ± 300 |
1620 ± 20 |
nd |
105 |
|
hTWEAK (TNF-like weak inducer of apoptosis) concentration was 10 ng/ml; TNF (tumour necrosis factor) concentration was 1 ng/ml. Values for IL-8, matrix metalloproteinase-1 (MMP-1), prostaglandin E2 (PGE-2) and interferon-γ-inducible protein-10 (IP-10) are shown as mean ± SD; similar results were obtained in 3 independent experiments. Single analyses for RANTES (regulated on activation, normal T expressed and secreted) were done because the amount of available medium was limited. nd, not done. | ||||
Chicheportiche et al. Arthritis Res 2002 4:126 doi:10.1186/ar388 |
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