Figure 2.

Pathways of nitric oxide (NO) formation and effects on articular chondrocytes. COX = cyclooxygenase, IL-1Ra = interleukin-1 receptor antagonist, iNOS = inducible nitric oxide synthase, NF = nuclear factor, PGs = prostaglandins, - refers to inhibition; + to stimulation. Reproduced from figure 110.3 with permission from [80].