Table 1

The frequency and severity of arthritis triggered by intra-articular injection of 100 µg of peptidoglycan in mice depleted of neutrophils, NK cells, or monocytes

Group

Mice

Incidence

Severity


RB6-8C5

BALB/c

10/10

2.0 ± 0.7

Control

BALB/c

9/9

2.3 ± 0.8

PK136

C57BL/6

10/10

1.8 ± 0.8

Control

C57BL/6

10/10

2.2 ± 0.6

Etoposide

C57BL/6

8/8

1.6 ± 0.7

Control

C57BL/6

10/10

2.1 ± 0.5

SCID

CB17

9/9

1.6 ± 0.7

Control

CB17

10/10

2.7 ± 0.5


RB6-8C5 is an IgG2b antibody that depletes neutrophils in BALB/c mice. Etoposide is a cytotoxic drug that selectively depletes monocytes. PK136 is an IgG2a antibody that depletes natural killer cells. SCID mice lack T and B cells.

Liu et al. Arthritis Res 2001 3:375-380   doi:10.1186/ar330

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