Table 1 |
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The frequency and severity of arthritis triggered by intra-articular injection of 100 µg of peptidoglycan in mice depleted of neutrophils, NK cells, or monocytes |
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| Group |
Mice |
Incidence |
Severity |
|
|
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| RB6-8C5 |
BALB/c |
10/10 |
2.0 ± 0.7 |
| Control |
BALB/c |
9/9 |
2.3 ± 0.8 |
| PK136 |
C57BL/6 |
10/10 |
1.8 ± 0.8 |
| Control |
C57BL/6 |
10/10 |
2.2 ± 0.6 |
| Etoposide |
C57BL/6 |
8/8 |
1.6 ± 0.7 |
| Control |
C57BL/6 |
10/10 |
2.1 ± 0.5 |
| SCID |
CB17 |
9/9 |
1.6 ± 0.7 |
| Control |
CB17 |
10/10 |
2.7 ± 0.5 |
|
|
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|
RB6-8C5 is an IgG2b antibody that depletes neutrophils in BALB/c mice. Etoposide is a cytotoxic drug that selectively depletes monocytes. PK136 is an IgG2a antibody that depletes natural killer cells. SCID mice lack T and B cells. |
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Liu et al. Arthritis Res 2001 3:375 doi:10.1186/ar330 |
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