Severity of arthritis in NMRI mice after intra-articular inoculation with intact and digested peptidoglycan. The knee joints were inoculated with peptidoglycan (PGN) (100 µg/joint), PGN digested by lysostaphin (180 µg/joint), lysostaphin alone (150 µg/joint), PGN digested by cellosyl (180 µg/joint), or cellosyl alone (150 µg/joint) (n = 5 per group). All mice were killed three days after the inoculation and histopathological examination was performed. Values are shown as mean ± SD.
Liu et al. Arthritis Res 2001 3:375 doi:10.1186/ar330