Table 1 |
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|
Proteoglycans (PGs) and proteins of the cartilage extracellular matrix |
|
| Proteoglycans |
Proteins |
|
|
|
| Aggregating |
Structural |
| Aggrecan |
COMP (Thrombospondin-5) |
| Versican |
Thrombospondin-1 and -3 |
| Link protein |
CMP (Matrilin-1) |
| Leucine-rich repeat |
Matrilin-3 |
| Biglycan (DS-PGI) |
CILP |
| Decorin (DS-PGII) |
C-type lectin |
| Epiphycan (DS-PGIII) |
Fibronectin |
| Fibromodulin |
PRELP |
| Lumican |
Chondroadherin |
| Other |
Tenascin-C |
| Perlecan |
Fibrillin |
| SZP/Lubricin |
Elastin |
| Regulatory |
|
| gp-39/YKL-40 |
|
| Matrix gla protein/ MGP |
|
| Pleiotrophin |
|
| Chondromodulin-I/SCGP |
|
| Chondromodulin-II |
|
| CD-RAP |
|
| Growth factors |
|
| Other |
|
| Chondrocalcin |
|
| PARP |
|
| Lysozyme |
|
| Phospholipase A2 |
|
| Proteinases and inhibitors |
|
|
|
|
|
CD-RAP = cartilage-derived retinoic acid responsive protein; CILP = cartilage intermediate layer protein; CMP = cartilage matrix protein; COMP = cartilage oligomeric matrix protein; DS-PG(I, II, III) = dermatan sulfate proteoglycan (I, II, III); gla = gamma-carboxyglutamic acid; gp = glycoprotein; PARP = proline- and arginine-rich protein; PRELP = proline- and arginine-rich end leucine-rich repeat protein; SZP = superficial zone protein. |
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Roughley Arthritis Res 2001 3:342 doi:10.1186/ar326 |
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