|
Summary of human linkage studies in systemic lupus erythematosus |
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| Moser et al |
Gaffney et al |
Gaffney et al |
Shai et al |
Lindqvist et al |
|
| Study parameter |
(1998) [15] |
(1998) [16] |
(2000) [17] |
(1999) [18] |
(2000) [19] |
|
|
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| Number of families |
94 |
105 |
82 |
80 |
19 |
| Type of study |
Extended |
Sib-pair |
Sib-pair |
Extended |
Extended |
| pedigrees |
pedigrees |
pedigrees |
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| Number of affected individuals |
220 |
220 |
179 |
188 |
44 |
| Number of unaffected individuals |
313 |
155 |
101 |
246 |
52 |
| Number of ethnic groups |
2 |
5 |
4 |
2 |
1 |
| Ethnicity of families studied |
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| White |
0 |
84 |
64 |
37 |
19 |
| Mexican American |
0 |
0 |
0 |
43 |
0 |
| African American |
31 |
6 |
12 |
0 |
0 |
| Hispanic |
0 |
8 |
5 |
0 |
0 |
| European American |
55 |
0 |
0 |
0 |
0 |
| Asian |
0 |
3 |
0 |
0 |
0 |
| Mixed heritage |
0 |
4 |
1 |
0 |
0 |
| Number of loci analysed |
312 |
341 |
366 |
350 |
336 |
| Basis of linkage |
LOD = 1.5 |
LOD = 1.0 |
LOD = 1.0 |
NPLZ >1.5 |
LOD = 1.0 |
| Statistical methods |
Model-based, |
Nonparametric |
Nonparametric |
Nonparametric |
Model-based |
| then nonparametric |
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|
Information taken from from references [15,16,17,18,19]. LOD = logarithm of the odds; NPLZ = nonparametric linkage Zall statistic. | |||||
Ahmad and Bruce Arthritis Res 2001 3:331 doi:10.1186/ar324 |
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