Bone loss: Therapeutic approaches for preventing bone loss in inflammatory arthritis
University of California, San Francisco, CA, USA
Arthritis Res Ther 2001, 3:221-227 doi:10.1186/ar305Published: 18 May 2001
Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.