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Review

Angiogenesis in the pathogenesis of inflammatory joint and lung diseases

David A Walsh* and Claire I Pearson

Author Affiliations

Academic Rheumatology, University of Nottingham Clinical Sciences Building, City Hospital, Nottingham, UK

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Arthritis Res 2001, 3:147-153  doi:10.1186/ar292

Published: 23 February 2001

Abstract

This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process for growth and tissue repair after injury. Nevertheless, it may contribute to a variety of chronic inflammatory diseases, including rheumatoid arthritis, osteoarthritis, asthma, and pulmonary fibrosis. Inflammation can promote angiogenesis, and new vessels may enhance tissue inflammation. Angiogenesis in inflammatory disease may also contribute to tissue growth, disordered tissue perfusion, abnormal ossification, and enhanced responses to normal or pathological stimuli. Angiogenesis inhibitors may reduce inflammation and may also help to restore appropriate tissue structure and function.

Keywords:
angiogenesis; arthritis; interstitial lung disease; joint disease; neovascularisation