Table 1

Differential activation of MAPK/SAPK in the synovial subcompartments of RA

Signalling pathway

Synovial-lining layer

Sublining layer

Mononuclear infiltrates

Perivascular region

Vascular endothelium

p38

+++

+

+

-

+++

ERK

-

+

-

+++

-

JNK

+

++

++

+

-

Schett et al. Arthritis Res 2001 3:80   doi:10.1186/ar144