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Open Access Research article

Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8

Kenji Hayashida1, Toshihiro Nanki1, Hermann Girschick1, Sule Yavuz1, Takahiro Ochi2 and Peter E Lipsky1*

Author Affiliations

1 University of Texas, Southwestern Medical Center, Dallas, Texas, USA

2 Osaka University Medical School, Suita, Osaka, Japan

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Arthritis Res 2001, 3:118-126  doi:10.1186/ar149

Published: 5 January 2001

Abstract

Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally.

Keywords:
chemokine; monocyte; rheumatoid arthritis