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Highly Accessed Review

Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis

Linda J Sandell1* and Thomas Aigner2

Author Affiliations

1 Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, USA

2 Cartilage Research - Department of Pathology, University of Erlangen-Nurnberg, Erlangen, Germany

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Arthritis Res 2001, 3:107-113  doi:10.1186/ar148

Published: 22 January 2001

Abstract

The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: (1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and (3) degradation; (4) phenotypic modulation of the articular chondrocytes; and (5) formation of osteophytes. In osteoarthritis, the primary responses are reinitiation of synthesis of cartilage macromolecules, the initiation of synthesis of types IIA and III procollagens as markers of a more primitive phenotype, and synthesis of active proteolytic enzymes. Reversion to a fibroblast-like phenotype, known as 'dedifferentiation', does not appear to be an important component. Proliferation plays a role in forming characteristic chondrocyte clusters near the surface, while apoptosis probably occurs primarily in the calcified cartilage.

Keywords:
cartilage; cell biology; chondrocyte phenotype; osteoarthritis