Table 2

Soluble mediators regulating fibroblast proliferation

Effect

Factors

Examples of cellular and tissue source

Reference


+

AMDGF

Alveolar macrophage

[16]

+

aFGF, bFGF

Brain, retina, bone matrix, endothelial cells, macrophage

[17]

+

CTAP-III

Platelet

+

CTAP-V

Platelet

+

CTAP-PMN

PMN

+

EGF and TGF-α

Granulocyte, ectodermal cells, kidney, duodenal gland, platelet

[18]

-

Interferon-γ

T lymphocyte, NK cell

[19]

+

IGF-I (SmC)

Fibroblast, skeletal cell, liver, endothelial cell, T cell

[20]

+

IGF-II (MSA)

Liver

[21]

+

IL-1α and IL-β

Monocyte/macrophage, Langerhans cell, other dendritic cells, T lymphocyte, B lymphocyte,

NK cell, large granular lymphocyte, vascular endothelial cell, smooth muscle cell, fibroblast,

thymic epithelial cell, astrocyte, microglia, keratinocyte, chondrocyte

+

IL-1 inhibitor

Monocyte

[22]

+

PDGF-AA, PDGF-BB,

Platelet, macrophage, endothelial cell, fibroblasts, vascular smooth cells, glial cell, type I astrocyte,

PDGF-AB

kidney, epithelial cell, mesangial cells

+

TCDGF

T cell

[23]

+

TGF-β

Platelets, macrophage, T cell, skeletal muscle cell, fibroblast

[24]

+

TNF-β

Lymphocyte

[25]


+, Stimulation; -, inhibition. aFGF, acidic fibroblast growth factor; AMDGF, alveolar macrophage-derived growth factor; bFGF, basic fibroblast growth factor; CTAP, connective tissue-activating peptide; EGF, epidermal growth factor; IGF, insulin-like growth factor; IL, interleukin; NK, natural killer; PDGF, platelet derived growth factor; PMN, polymorphonuclear cell; TCDGF, T cell derived growth factor; TGF, transforming growth factor; TNF, tumor necrosis factor.

Konttinen et al. Arthritis Res 2000 2:348-355   doi:10.1186/ar111