Table 1

Soluble mediators regulating fibroblast migration

Effect

Factor

Cellular or tissue source

Reference


+

TNF-α

Macrophage, activated monocyte, B cell, T cell, fibroblast

[2]

+

IL-4

T cell, mast cell, bone marrow stromal cell

[3]

+

PDGF-AA, -BB, -AB

Platelet, macrophage, endothelial cell, skeletal muscle cell, fibroblast, vascular smooth

[3]

muscle cell, glial cell, type I astrocyte, myoblast, kidney, epithelial cell, mesangial cell

+

TGF-β

Platelet, macrophage, T cell, skeletal muscle cell, fibroblast

[4]

+

bFGF

Brain, retina, bone matrix, endothelial cell, macrophage

[3]

+

EGF

Granulocyte, ectodermal cell, kidney, duodenal gland, platelet

[5]

+

Neurokinin A

Nerve cell

[3]

+

CGRP

Nerve cell

[6]

+

Endothelin-1 and -3

Endothelial cell, macrophage, fibroblast, many other cells

[3]

+

β -thromboglobulin

Platelet, megakaryocyte

[1]

+

Platelet factor 4

Platelet, megakaryocyte

[1]

LTB4

Myeloid cells, from transported LTA4 in many nonmyeloid and nonhematopoietic cells

[3]

+

IGF-I (SmC)

Fibroblast, skeletal cell, liver, endothelial cell, T cell

[7]

+

IGF-II (MSA)

Liver

[3]

+

Matrix proteins

Collagen

ECM

[8]

Fibronectin

ECM

[9]

Elastin

ECM

[10]

+

Serum derived

Complement (C5)

[11,12]

chemotactic factor

for fibroblasts

-

Interferon

T lymphocyte, NK cell (interferon-γ), all cells (interferon-α)

[13]

-

Retinoids

[14]

-

Neutrophil factor

Neutrophil

[15]


+, Stimulation; -, inhibition. bFGF, basic fibroblast growth factor; CGRP, calcitonin gene-related peptide; ECM, extracellular matrix; EGF, epidermal growth factor; IGF, insulin-like growth factor; IL, interleukin; LTA, leukotriene A; LTB, leukotriene B; NK, natural killer; PDGF, platelet derived growth factor; TGF, transforming growth factor; TNF, tumor necrosis factor.

Konttinen et al. Arthritis Res 2000 2:348-355   doi:10.1186/ar111