Fibroblast biology: Development and differentiation of synovial fibroblasts in arthritis
UCL Centre for Rheumatology, London, UK
Arthritis Res 2000, 2:344-347 doi:10.1186/ar110Published: 8 June 2000
Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.