Table 1 |
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Clinical outcome and treatment-related morbidity of patients with polychondritis or SLE in complete remission |
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Patient* |
Follow up (months) |
ANA† |
Anti-double-stranded DNA† ELISA‡ (U/ml) CL-IF |
Cardiolipin†§ (U/ml) IgG/IgM |
Other parameters† |
Complement† (md/dl) C3/C4 |
Steroid dosage (mg/day)†¶ |
Karnofsky score (%)† |
ECLAM score† |
Side effects during immunoablation |
|
|
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1 PC/female/41 years/1985 |
21 |
No relevance |
No relevance |
No relevance |
Tracheal involvement, costosternal pain, arthralgias |
No relevance |
62.5 |
60 |
No relevance |
SIRS**: WHO grade IV Local infection Interstitial pneumonia and capillary leakage DIC Reactivation of gastrointestinal ulcer |
|
↓ |
↓ |
↓ |
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Complete resolution |
3 |
100 |
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|
|
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|
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|
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2 SLE/female/27 years/1987 |
19 |
1:5120 |
518 / 1:64 |
38 / 54 |
∅ |
82 / 10 |
35 |
40 |
6.5 |
SIRS**: WHO grade IV Septicaemia and pneumonia in aplasia: WHO grade I Flares of disease (abdominal vasculitis, arthralgias, serositis) |
|
↓ |
↓ ↓ |
↓ ↓ |
↓ ↓ |
↓ |
↓ |
↓ |
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|
Negligible |
<cut-off ∅ |
<31 <31 |
140 22 |
5 |
100 |
2 |
|
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|
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|
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3 SLE/female/48 years/1993 |
16 |
1:5120 |
5040 / 1:128 |
88 / 379 |
α -Ro+ |
122 / 14 |
20 |
60 |
6 |
SIRS**: WHO grade IV Septicaemia Local infection Liver haematoma: WHO grade II SIRS**: WHO grade IV |
|
↓ |
↓ ↓ |
↓ ↓ |
↓ |
↓ ↓ |
↓ |
↓ |
↓ |
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|
1:80 |
<cut-off ∅ |
<31 <31 |
∅ |
164 27 |
4 |
100 |
2 |
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4 SLE/male/37 years/1989 |
10 |
1:2560 |
976 / 1:128 |
33 / 56 |
α-Ro/ Proteinuria α-La+ 8.8 g/day |
<44 / <5 |
100 |
70 |
10 |
|
|
↓ |
↓ ↓ |
↓ ↓ |
↓ ↓ |
↓ ↓ |
↓ |
↓ |
↓ |
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|
1:160 |
<cut-off ∅ |
<31 <31 |
∅ 0.8 g/day |
120 22 |
5 |
100 |
2 |
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*Characteristics: number/disease/sex/age/year of diagnosis. †Values above the arrow represent the admission values and those below the arrow represent the present status. ‡ELISA cut-off was 118 iU/ml. §The cut-offs for IgG and IgM anticardiolipin were 48 and 44 U/ml, respectively. ¶Doses corresponding to prednisolone equivalents. **SIRS due to application of cyclophosphamide and ATG. CL-IF, Crithidia luciliae immunofluorescence; PC, relapsing polychondritis; DIC, disseminated intravascular coagulation; ELISA, enzyme-linked immunosorbent assay; SIRS, systemic inflammatory response syndrome; WHO, World Health Organization. |
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Rosen et al. Arthritis Res 2000 2:327 doi:10.1186/ar107 |
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