Table 1

Clinical outcome and treatment-related morbidity of patients with polychondritis or SLE in complete remission

Patient*

Follow up (months)

ANA

Anti-double-stranded DNA ELISA (U/ml) CL-IF

Cardiolipin†§ (U/ml) IgG/IgM

Other parameters

Complement (md/dl) C3/C4

Steroid dosage (mg/day)†¶

Karnofsky score (%)

ECLAM score

Side effects during immunoablation


1     PC/female/41 years/1985

21

No relevance

No relevance

No relevance

Tracheal involvement, costosternal pain, arthralgias

No relevance

62.5

60

No relevance

SIRS**: WHO grade IV Local infection Interstitial pneumonia and capillary leakage DIC Reactivation of gastrointestinal ulcer

Complete resolution

3

100

 

 

 

2 SLE/female/27 years/1987

19

1:5120

518  /  1:64

38    /    54

82    /    10

35

40

6.5

SIRS**: WHO grade IV Septicaemia and pneumonia in aplasia: WHO grade I Flares of disease (abdominal vasculitis, arthralgias, serositis)

   ↓         ↓

↓         ↓

↓          ↓

Negligible

<cut-off  ∅

<31     <31

140       22

5

100

2

 

 

 

3 SLE/female/48 years/1993

16

1:5120

5040 / 1:128

88 / 379

α -Ro+

122   /   14

20

60

6

SIRS**: WHO grade IV Septicaemia Local infection Liver haematoma: WHO grade II SIRS**: WHO grade IV

   ↓         ↓

↓         ↓

↓         ↓

1:80

<cut-off  ∅

<31     <31

164      27

4

100

2

 

 

 

4    SLE/male/37 years/1989

10

1:2560

976 / 1:128

33   /   56

α-Ro/  Proteinuria α-La+   8.8 g/day

<44  /  <5

100

70

10

   ↓         ↓

↓         ↓

  ↓            ↓

↓         ↓

1:160

<cut-off  ∅

<31     <31

  ∅    0.8 g/day

120     22

5

100

2


*Characteristics: number/disease/sex/age/year of diagnosis. Values above the arrow represent the admission values and those below the arrow represent the present status. ELISA cut-off was 118 iU/ml. §The cut-offs for IgG and IgM anticardiolipin were 48 and 44 U/ml, respectively. Doses corresponding to prednisolone equivalents. **SIRS due to application of cyclophosphamide and ATG. CL-IF, Crithidia luciliae immunofluorescence; PC, relapsing polychondritis; DIC, disseminated intravascular coagulation; ELISA, enzyme-linked immunosorbent assay; SIRS, systemic inflammatory response syndrome; WHO, World Health Organization.

Rosen et al. Arthritis Res 2000 2:327-336   doi:10.1186/ar107

Open Data