Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells
1 University Hospital Charité (Campus Mitte), Germany
2 German Research Center for Rheumatology, Berlin, Germany
3 Rheumaklinik Berlin-Buch, Berlin, Germany
Arthritis Res 2000, 2:327-336 doi:10.1186/ar107Published: 8 June 2000
Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondritis and systemic lupus erythematosus (SLE), even at advanced stage, with the use of autologous stem-cell transplantation (SCT). Remissions persisted after reconstitution of the immune system. In the treatment of advanced systemic sclerosis (SSc), stable disease may be achieved with autologous SCT.