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Open Access Research article

Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells

Oliver Rosen1, Andreas Thiel2, Gero Massenkeil1, Falk Hiepe1, Thomas Häupl1, Hartmut Radtke1, Gerd R Burmester1, Erika Gromnica-Ihle3, Andreas Radbruch2 and Renate Arnold1

Author Affiliations

1 University Hospital Charité (Campus Mitte), Germany

2 German Research Center for Rheumatology, Berlin, Germany

3 Rheumaklinik Berlin-Buch, Berlin, Germany

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Arthritis Res 2000, 2:327-336  doi:10.1186/ar107

Published: 8 June 2000

Abstract

Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondritis and systemic lupus erythematosus (SLE), even at advanced stage, with the use of autologous stem-cell transplantation (SCT). Remissions persisted after reconstitution of the immune system. In the treatment of advanced systemic sclerosis (SSc), stable disease may be achieved with autologous SCT.

Keywords:
autologous stem-cell transplantation; polychondritis; refractory autoimmune disease; systemic lupus erythematosus; systemic sclerosis