Table 1

Determinants of immune reconstitution after HDIT and SCT

Age-dependent thymopoiesis in children versus adults [5**,6*,7,9*,10*,11]

Source of hematopoietic stem cells:

allogeneic versus autologous [8*];

bone marrow versus peripheral blood [8*,13,41*,42]

Mobilization protocol: G-CSF alone versus chemotherapy and G-CSF [42]

Conditioning regimen: myeloablative versus intensive

immunosuppressive [5**]

Manipulation of graft (ex vivo T-cell depletion or CD34 enrichment)

versus in vivo T-cell depletion versus nonmanipulation of graft

[5**,16**,17*,18*,19,20**]

Pre- and post-transplant treatment? [43]

Underlying rheumatic disease?


van Laar Arthritis Res 2000 2:270-275   doi:10.1186/ar101