Table 3

Diagnostic value of individual autoantibodies for rheumatoid arthritis

Sensitivity
 Specificity
 PPV
 NPV
 Accuracy
RF
 0.66
 0.87
 0.80
 0.76
 0.78
AFA
 0.33
 0.93
 0.79
 0.63
 0.66
Anti-Sa
 0.22
 0.98
 0.88
 0.61
 0.64
Anti-CCP
 0.41
 0.91
 0.78
 0.66
 0.69
AKA
 0.26
 0.84
 0.56
 0.58
 0.58
RF+ and one or more*
 0.50
 0.96
 0.90
 0.70
 0.75
RF- and one or more*
 0.31
 0.73
 0.26
 0.77
 0.63

* Includes antifilaggrin antibody (AFA), anti-Sa, cyclic citrullinated peptide (anti-CCP) and antikeratin antibody (AKA). PPV, positive predictive value; NPV, negative predictive value; RF, rheumatoid factor.

Goldbach-Mansky et al. Arthritis Res 2000 2:236   doi:10.1186/ar93

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