Death, autoantigen modifications, and tolerance

doi:10.1186/ar75

Arthritis Res

Volume 2
Issue 2

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Gensler TJ
Anderson P

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Anderson P
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Review

Death, autoantigen modifications, and tolerance

Paul J Utz,¹ , Timothy J Gensler² and Paul Anderson²

¹Stanford University School of Medicine, Stanford, California, USA

²Brigham and Women's Hospital, Boston, Massachusetts, USA

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Arthritis Res 2000, 2:101-114doi:10.1186/ar75


Published:	9 February 2000

Abstract

Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The mechanisms governing the generation of autoantibodies remain elusive, constituting a critical missing link in our understanding of rheumatologic illnesses. Several lines of experimentation in recent years have strongly implicated events surrounding cell death in this process. This review will address the potential role played by death-specific modifications of autoantigens in bypassing tolerance to highly conserved autoantigens, including nucleic acids, lipids, and proteins.