Relationships between CK and SCr and CRP using Phase 3 data. (A) CK increases at Week 12 by baseline CRP; baseline CRP Q1 < < Q4. (B) CK increases at Month 3 by change in CRP at Month 3; reductions in CRP Q1 > > Q4. (C) SCr increases at Month 3 by change in CK at Month 3; reductions in CK Q1 > > Q4.
Isaacs et al. Arthritis Research & Therapy 2014 16:R158 doi:10.1186/ar4673