Open Access Highly Accessed Research article

Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

Bridgette D Furman1, Daniel S Mangiapani1, Evan Zeitler1, Karsyn N Bailey1, Phillip H Horne1, Janet L Huebner2, Virginia B Kraus2, Farshid Guilak1 and Steven A Olson1*

Author Affiliations

1 Department of Orthopaedic Surgery, Duke University Medical Center, Box 3389, Durham, NC 27710, USA

2 Department of Medicine, Duke University Medical Center, Box 104775, Durham, NC 27710, USA

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Arthritis Research & Therapy 2014, 16:R134  doi:10.1186/ar4591

Published: 25 June 2014

Additional files

Additional file 1:

Native serum levels of mouse IL-1Ra or soluble TNF receptor II (sTNFRII). Native levels of mouse IL-1Ra or sTNFRII were quantified in serum obtained at time of sacrifice in those animals that received either local or systemic administration of saline, IL-1Ra or sTNFRII following articular fracture.

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Additional file 2:

Bone morphology measured by micro computed tomography (microCT). Bone morphology was assessed for the contralateral control (R) and fractured limbs (L) in the tibial plateau, tibial metaphysis, and femoral condyles.

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