Open Access Highly Accessed Research article

Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility

Chanchal Sur Chowdhury1, Stavros Giaglis12, Ulrich A Walker3, Andreas Buser4, Sinuhe Hahn1* and Paul Hasler2*

Author Affiliations

1 Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4032 Basel, Switzerland

2 Department of Rheumatology, Kantonsspital Aarau, Tellstrasse, 5001 Aarau, Switzerland

3 Department of Rheumatology, University Hospital Basel, Basel, Switzerland

4 Division of Haematology, Department of Internal Medicine, University Hospital Basel, Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland

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Arthritis Research & Therapy 2014, 16:R122  doi:10.1186/ar4579

Published: 13 June 2014

Additional files

Additional file 1: Figure S1:

Neutrophil, peripheral blood leukocyte counts, and age distribution in RA cases and control cohorts.

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Additional file 2: Table S1:

AUC values with corresponding 95% confidence intervals, P values and standard errors for serum cell-free nucleosomes and the three different parameters, which were analyzed individually by logistic regression.

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Additional file 3: Figure S2:

Elevated serum levels of NET components, in RA patients, have potential clinical utility.

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