Table 1

Common multipotential stromal cell genes
Fold changing in expression between:
Gene HN/FB SF/FB ICBM/FB
ACVR2A Activin A receptor, type IB 2.8 3.5 7.0
ANGPT1 Angiopoietin 1 5.3 4.6 4.9
BAMBI Bone morphagenietic protein and activin membrane-bound inhibitor homolog 18.2 36.8 10.2
CDH11 Cadherin 11 11.4 8.8 9.0
COL1A1 Collagen, type I, alpha 1 15.3 4.3 6.0
COL1A2 Collagen, type I, alpha 2 20.2 20.8 9.9
CXCL12 Chemokine ligand 12 3.1 5.4 1.9
EPHB4 Ephrin receptor B4 5.5 2.3 2.6
FZD1 Frizzled family receptor 1 4.7 11.5 4.6
GDF5a Growth differentiation factor 5 73.5 4.04 25.5
GJA1 Gap junction protein, alpha 1 8.2 14.7 10.2
HAPLN1a Hyaluronan and proteoglycan link protein 1 397.3 258.5 691.3
IGFBP3 Insulin-like growth factor-binding protein 3 59.5 107.8 5.1
MYH9a Myosin heavy chain 9 6.0 6.0 6.8
PAPSS2 3′-phosphoadenosine 5′-phosphosulfate synthase 2 2.8 5.1 2.7
RUNX1 Runt-related transcription factor 1 3.0 59.0 1.9
SFRP4 Secreted frizzled-related protein 4 171.2 908.9 4.8
SORT1 Sortilin 1 4.4 8.9 11.1
SPARC Secreted protein, acidic, cysteine-rich 7.0 7.0 7.1
VEGFC Vascular endothelial growth factor C 3.1 10.2 1.6

Relative fold change in expression compared with fibroblasts (FBs) (P ≤0.05, Mann-Whitney U). aNewly identified genes. HN, Heberden’s node; ICBM, normal iliac crest bone marrow; SF, synovial fluid.

Baboolal et al.

Baboolal et al. Arthritis Research & Therapy 2014 16:R119   doi:10.1186/ar4574

Open Data