Interleukin 27 inhibited production interleukin 1β, interleukin 6 and interleukin 23, but promoted production of interleukin 10, by dendritic cells. (A) through (D) Interleukin 1β (IL-1β), IL-6, IL-23 and IL-10 in the supernatants of monocyte-derived dendritic cells (DCs) (monocyte-derived DCs from three healthy controls and two patients with active BD) stimulated with lipopolysaccharide in the absence or presence of IL-27 (100 ng/ml) for 48 hours were measured by enzyme-linked immunosorbent assay. Paired-samples t-tests for related samples were used for statistical analysis. All of the data are representative of three independent experiments with cells five donors and are expressed as average ± standard deviation.
Wang et al. Arthritis Research & Therapy 2014 16:R117 doi:10.1186/ar4570