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Open Access Highly Accessed Editorial

Goldilocks, vitamin D and sarcoidosis

Robert P Baughman12* and Elyse E Lower1

Author Affiliations

1 Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA

2 1001 Holmes Building, Eden Ave, Cincinnati, OH 45267-0565, USA

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Arthritis Research & Therapy 2014, 16:111  doi:10.1186/ar4568


See related research by Saidenberg-Kermanac’h et al., http://arthritis-research.com/content/16/2/R78

Published: 23 May 2014

Abstract

While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac’h and colleagues compared vitamin D levels with bone fragility fractures in their sarcoidosis clinic. They found that a 25-(OH) vitamin D level between 10 and 20 ng/ml was associated with the lowest risk of bone fractures and paradoxically higher levels increased the risk of bone fractures. Using less vitamin D supplementation may simultaneously lower the risk for bone fracture and hypercalcemia in sarcoidosis.