Additional file 6: Figure S3.
(A) Heatmap visualization of processes enriched in downregulated genes in each of the four synovial clusters defined in Figure 1A using the Database for Annotation, Visualization and Integrated Discovery (DAVID) pathway analysis tool. Colors refer to statistical significance of processes to each cluster. (B) Assessment of overlap between biological process gene sets utilized by the DAVID pathway analysis tool for downregulated genes in each of the four synovial clusters defined in Figure 1A. The overlap of genes shared by gene sets are illustrated using a heatmap where each value represents the proportion of genes from the category on the y-axis that are in common with the corresponding gene set on the x-axis (indicated by the color bar; 0 = 0%, 1 = 100%). The matrix is not symmetrical because the size of the gene sets is not constant.
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Dennis et al. Arthritis Research & Therapy 2014 16:R90 doi:10.1186/ar4555