Expression of Mer on monocytes and myeloid dendritic cells in patients with SLE correlates with IFN-I activity. Interferon activity influences the proportion of monocytes and myeloid dendritic cells in blood. (A) IFN-I activity in plasmas from normal individuals and SLE patients. The optical density units obtained for plasma-induced alkaline phosphatase activity in plasmas are shown. Mer levels on (B) CD14intCD16+ monocyte and (C) CD14++CD16- and CD1c+ DC subsets positively correlate with IFN-I activity. The proportions of (D) CD14intCD16+ monocytes, (E) CD14++CD16- monocytes, and (F) CD1c+ myeloid dendritic cell subsets negatively correlate with IFN-I activity. Spearman rank correlation was used to determine significance. Values for Spearman r and P values are given for the different correlates.
Hilliard et al. Arthritis Research & Therapy 2014 16:R76 doi:10.1186/ar4517