Table 2

Multivariate linear regression analyses of each SNP associated with serum 25(OH)D concentration
Locus SNP MAF β SE P-value
GC rs2282679 0.259 (A/C) -0.13 0.033 8.1 × 10-5
DHCR7/NADSYN1 rs3829251 0.375 (G/A) -0.0031 0.032 0.92
rs12785878 0.328 (G/T) 0.0057 0.032 0.86
rs1790349 0.361 (A/G) -0.016 0.032 0.63
CYP2R1 rs10741657 0.387 (G/A) 0.035 0.034 0.30

All analyses were adjusted for independent non-genetic risk factors: gender, age, Japanese version of the Health Assessment Questionnaire disability score, total protein level, total cholesterol level, alkaline phosphate level, and non-steroidal anti-inflammatory drugs use [12]. Alleles are listed as major allele/minor allele. SNP, single nucleotide polymorphism; MAF, minor allele frequency; SE, standard error; GC, group-specific component; DHCR7/NADSYN1, 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1; CYP2R1, cytochrome P450, family 2, subfamily R, polypeptide 1.

Yoshida et al.

Yoshida et al. Arthritis Research & Therapy 2014 16:R75   doi:10.1186/ar4516

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