SLE patients with IFN type I signature show higher percentages of IL-17A and IL-17A/IL-17 F producing CCR6+ cells. (A-D). Proportions of IL-17A (A), IL-17 F (B), IL-22 (C), and IL-21 (D) expressing cells within CCR6+ memory T-cell population in PBMCs of IFN- (n = 9) and IFN+ (n = 16) patients and HC (n = 15). All proportions were measured by intracellular flow cytometry. Horizontal line indicates median. *P < 0,05; **P < 0,01; to compare means, a Kruskal-Wallis test was used followed by Mann–Whitney U test.
Brkic et al. Arthritis Research & Therapy 2014 16:R62 doi:10.1186/ar4499