Open Access Highly Accessed Research article

T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?

Zana Brkic1, Odilia BJ Corneth12, Cornelia G van Helden-Meeuwsen1, Radboud JEM Dolhain2, Naomi I Maria1, Sandra MJ Paulissen12, Nadine Davelaar12, Jan Piet van Hamburg12, Paul L van Daele1, Virgil A Dalm1, P Martin van Hagen1, Johanna MW Hazes2, Marjan A Versnel1 and Erik Lubberts12*

Author Affiliations

1 Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, P.O. Box 1738, Rotterdam 3000 DR, The Netherlands

2 Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, P.O. Box 1738, Rotterdam 3000 DR, The Netherlands

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Arthritis Research & Therapy 2014, 16:R62  doi:10.1186/ar4499

Published: 6 March 2014

Additional files

Additional file 1: Figure S1:

(A) Representative graphs of proportions of IL-17A- and IL-17F-expressing cells within CCR6+ memory T-cell population (defined as CD4+CD45RO+CD25-CCR6+) in PBMCs of IFN negative (IFN-) and IFN positive (IFN+) patients and healthy controls (HCs). (B) Representative graphs of proportions of IL-17A and IL-22-expressing cells within CCR6+ memory T-cell population in PBMCs of IFN- and IFN+ patients and HCs. (C) Representative graphs of proportions of IL-21-expressing cells within CCR6+ memory T-cell population in PBMCs of IFN- and IFN+ patients and HCs.

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