The daily glucocorticoid dose correlates with% CD4+CD25-Foxp3+ T cells and the systemic lupus erythematosus disease activity index (SLEDAI) disease activity score. (a) The daily glucocorticoid dose of systemic lupus erythematosus (SLE) patients was significantly correlated with the percentage of CD4+CD25-Foxp3+ T cells (r = 0.3; P = 0.02), and the absolute cell numbers of CD4+CD25-Foxp3+ T cells (r = 0.3; P = 0.02), as well as the SLEDAI score (r = 0.5; P = 0.0003). (b) Longitudinal analysis of the percentage of CD4+CD25-Foxp3+ T cells is shown in a patient with high disease activity treated with prednisone.
Bonelli et al. Arthritis Research & Therapy 2014 16:R104 doi:10.1186/ar4553