Open Access Highly Accessed Research article

CD4+CD25-Foxp3+ T cells: a marker for lupus nephritis?

Michael Bonelli, Lisa Göschl, Stephan Blüml, Thomas Karonitsch, Carl-Walter Steiner, Günter Steiner, Josef S Smolen and Clemens Scheinecker*

Author Affiliations

Division of Rheumatology, Internal Medicine III, General Hospital of Vienna, Medical University of Vienna (MUW), Waehringer Guertel 18-20, Vienna A-1090, Austria

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Arthritis Research & Therapy 2014, 16:R104  doi:10.1186/ar4553

Published: 28 April 2014

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Additional file 1: Figure S1:

CD4+CD25-Foxp3+ T cells correlate with regulatory T cells but not with activated T cells. CD4+CD25-Foxp3+ T cells from systemic lupus erythematosus (SLE) patients showed a significant correlation with CD4+CD25+Foxp3+ (r = 0.7; P <0.0001) but not with CD4+ CD25+Foxp3- (r = 0.17; P = 0.32).

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Additional file 2: Figure S2:

Increased absolute cell numbers of CD4+CD25-Foxp3+ T cells in patients with renal manifestation. Systemic lupus erythematosus (SLE) patients were divided into different groups according to their organ manifestations. In addition patients were subdivided into groups with active and no active organ involvement. A significant increase in absolute cell numbers of CD4+CD25-Foxp3+ T cells was observed in patients with renal involvement (P = 0.01) and in patients with active nephritis (P = 0.04). *Significant differences.

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