Figure 2.

Rheumatoid arthritis subjects have a lower proportion of IL-17A+ but a higher proportion of IFNγ+ CD4+ T cells compared with controls. (A) Circulating T-helper type (Th)17 and Th1 cells. Peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients and healthy controls were gated on CD3+CD4+ lymphocytes and were analyzed for expression of interleukin (IL)-17A (Th17 cells) and interferon gamma (IFNγ; Th1 cells) (Mann–Whitney U test). (B) Circulating CD161+ and TEM cells. PBMCs were gated on CD3+CD4+ lymphocytes and were analyzed for expression of CD161 and CD45RO (TEM cells) (Mann–Whitney U test). (C) CD161+IL17A+ population. PBMCs were gated on CD3+CD4+CD161+ and analyzed for expression of IL-17A and IFNγ (Mann–Whitney U test). (D) TEM IL-17A+ population. PBMCs were gated on CD3+CD4+CD45RO+ lymphocytes and were analyzed for expression of IL-17A and IFNγ (Mann–Whitney U test).

Bishu et al. Arthritis Research & Therapy 2014 16:R50   doi:10.1186/ar4480
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