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Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses

Shrinivas Bishu1, Ee Wern Su2, Erich R Wilkerson2, Kelly A Reckley2, Donald M Jones2, Mandy J McGeachy2, Sarah L Gaffen2* and Marc C Levesque2*

Author Affiliations

1 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA

2 Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, BST S702, 3500 Terrace Street, Pittsburgh, PA 15261, USA

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Arthritis Research & Therapy 2014, 16:R50  doi:10.1186/ar4480

Published: 11 February 2014

Additional files

Additional file 1: Figure S1:

(A) IL-17A production under Th17 differentiating conditions correlates with baseline IL-17A production. IL-17A production by PBMC co-cultures with Th17 differentiating cytokines was correlated to baseline IL-17A production by PBMCs by spearman’s coefficient. (B) IL-17 production to HK C. albicans correlates with the fraction of circulating Th17 cells. IL-17A production by PBMCs co-cultured with HK C. albicans was correlated to the fraction of circulating Th17 cells by Spearman’s coefficient.

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