Effect of μ-dHACM on MMT joints as depicted by histology. A-D) Representative H & E stained histology images of μ-dHACM treated MMT joints and saline treated MMT joints. μ-dHACM visible at three days as fibrillar eosinophilic material as indicated by the black arrows (A and C). Hypercellularity observed in the area around dHACM fragments. E-H) Representative Safranin-O stained histology images of tibia. Black arrows indicate damaged cartilage surface (H). No damage was observed in μ-dHACM treated MMT joints (G) whereas erosions and weak staining for PGs were observed in saline treated MMT joints (H) at 21 days. MMT, medial meniscal transection; PGs, proteoglycans; μ-dHACM, micronized dehydrated human amnion/chorion membrane.
Willett et al. Arthritis Research & Therapy 2014 16:R47 doi:10.1186/ar4476