Representative histology images of μ-dHACM treated joints and MCP-1 data. A-H) Representative histology images of μ-dHACM treated naïve joints and saline treated naïve joints. E-H are zoomed in versions of regions of interest (black box) defined in A-D, respectively. μ-dHACM is visible at three days as fibrillar eosinophilic material, as indicated by the black arrows (E and G). Hypercellularity was observed in areas around dHACM fragments. I) MCP-1 levels in μ-dHACM treated and saline injected naïve rats. MCP-1 levels were significantly higher at three days in both saline and μ-dHACM injected groups compared to twenty-one days. The MCP-1 level at three days was significantly higher in the μ-dHACM injected joints compared to saline treated joints. **P <0.05 for MCP-1 levels at three and twenty-one days for both groups. *P <0.05 for MCP-1 levels at day three in saline injected and μ-dHACM injected joints. n = 5. MCP-1, monocte chemoattractant protein-1; μ-dHACM, micronized dehydrated human amnion/chorion membrane.
Willett et al. Arthritis Research & Therapy 2014 16:R47 doi:10.1186/ar4476