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Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis

Jaecheol Lee123, Youngkyun Kim4, Hyoju Yi4, Sebastian Diecke123, Juryun Kim4, Hyerin Jung4, Yeri Alice Rim4, Seung Min Jung4, Myungshin Kim5, Yong Goo Kim5, Sung-Hwan Park4, Ho-Youn Kim4 and Ji Hyeon Ju1234*

Author Affiliations

1 Division of Cardiology, Department of Medicine, Stanford University School of Medicine, 265 Campus Drive, Room G1120B, Stanford, CA 94305-5454, USA

2 Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Room G1120B, Stanford, CA 94305-5454, USA

3 Stanford Cardiovascular Institute, Stanford University School of Medicine, 265 Campus Drive, Room G1120B, Stanford, CA 94305-5454, USA

4 Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea

5 Department of Laboratory Medicine, College of Medicine, Catholic Genetic Laboratory Center, Seoul St. Mary’s Hospital, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea

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Arthritis Research & Therapy 2014, 16:R41  doi:10.1186/ar4470

Published: 4 February 2014

Additional files

Additional file 1:

Is a table presenting the primer sequences used in the polymerase chain reaction.

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Additional file 2:

Is a figure showing positive expression of pluripotency markers on OA and RA iPSCs. Other clones were generated during the reprogramming process. Immunofluorescence staining against Nanog, Oct4, Sox2, Tra-1-80, Tra-1-60, and SSEA-4 in RA and OA iPSCs. RA and OA iPSCs expressed high level of these markers.

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