Additional file 2: Figure S2.

IL-17 derived from SSc patients induces collagen gene expression in fibroblasts. (A) Fibroblasts were stimulated with different concentrations of supernatants of PI-stimulated PBMCs from patients with active SSc (Active) and PI-stimulated PBMCs from healthy controls (Control) for 48 hours, and the gene expression of collagen 1 and collagen 3 was measured by real-time RT-PCR analysis. (B) Fibroblasts were stimulated with supernatants of PI-stimulated PBMCs from patients with active SSc (Active) and PI-stimulated PBMCs from healthy controls (Control) for different hours, and the gene expression of collagen 1 and collagen 3 was measured by real-time RT-PCR analysis. Results shown are representative of at least three independent experiments.

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Yang et al. Arthritis Research & Therapy 2014 16:R4   doi:10.1186/ar4430