Comparison of monoplex ALBIA-HMGCR and ALBIA-SRP to multiplex ALBIA-NAM. Serum from anti-HMGCR positive (n = 26) or anti-SRP positive (n = 25) patients were compared. (A) Correlation of the signals generated by ALBIA-NAM versus ALBIA-HMGCR. Mean fluorescence intensity (MFI) (B) Correlation of the signals generated by ALBIA-NAM versus ALBIA-SRP. (C) ALBIA-NAM discriminates anti-SRP positive from anti-HMGCR positive patients in a single assay. ALBIA, addressable laser bead immunoassay; HMGCR, 3-hydroxy-3-methylglutaryl coenzyme A reductase; SRP, signal recognition particle.
Drouot et al. Arthritis Research & Therapy 2014 16:R39 doi:10.1186/ar4468