Table 1

Baseline characteristics of patients by study and symptom duration group
Pooled data Etanercept Adalimumab
<4 years ≥4 years P-value <4 years ≥4 years P-value <4 years ≥4 years P-value
n = 58 n = 54 n = 42 n = 24 n = 16 n = 30
Symptom duration mean (SD) 2 (1.1) 7.7 (5) 2 (1.1) 5.2 (0.9) 1.9 (1) 9.7 (5.9)
Age, years, mean (SD) 31.7 (8.1) 37.8 (8.4) 0.001 31.6 (8.2) 37 (7.7) 0.01 31.8 (8.1) 38.5 (9.1) 0.02
Male, n (%) 30 (51.7) 28 (51.9) 0.99 25 (59.5) 12 (50) 0.45 5 (31.3) 16 (53.3) 0.15
HLA-B27-positive, n (%) 45 (77.6) 41 (75.9) 0.84 33 (78.6) 22 (91.7) 0.17 12 (75) 19 (63.3) 0.42
Joints with arthritis, mean (SD) 1.1 (3.3) 1.7 (6.4) 0.30 1.4 (3.9) 1.9 (6) 0.33 0.4 (0.7) 1.6 (6.7) 0.86
Joints with enthesitis, mean (SD) 2.5 (3.6) 3.5 (3.8) 0.095 2.7 (4) 3.7 (4.6) 0.41 2 (2.7) 3.3 (3.1) 0.16
BASDAI, mean (SD) 4.9 (1.9) 6 (1.8) 0.004 5 (1.7) 5.5 (2) 0.29 4.7 (2.4) 6.3 (1.5) 0.009
BASFI, mean (SD) 3.8 (2.4) 5 (2.1) 0.007 3.9 (2.2) 4.4 (2.3) 0.34 3.6 (2.8) 5.4 (1.9) 0.01
BASMI mean (SD) 1.5 (1.3) 2.1 (1.8) 0.057 1.7 (1.4) 2.6 (2) 0.04 1.1 (0.9) 1.7 (1.6) 0.16
ASDAS, mean (SD) 3.1 (0.9) 3.1 (0.8) 0.95 3.2 (0.8) 3 (1) 0.49 2.9 (0.9) 3.2 (0.6) 0.22
CRP, mg/l, mean (SD) 9 (9.3) 6.9 (9.6) 0.018 9.7 (10.4) 8.8 (13.4) 0.18 7.4 (6) 5.4 (5.2) 0.14
log CRP, mg/l, mean (SD) 2 (0.7) 1.7 (0.8) 0.018 2.1 (0.8) 1.8 (0.8) 0.26 1.9 (0.7) 1.5 (0.8) 0.16
CRP-negative, n (%) 26 (46.4) 37 (71.2) 0.009 18 (42.9) 16 (66.7) 0.04 8 (50) 21 (70) 0.18
MRI SIJ score, mean (SD) 6.2 (6.1) 4.1 (4.7) 0.08 6.4 (6) 5 (5.7) 0.21 5.4 (7) 3.2 (3.4) 0.61

P-value <0.05 was taken to indicate statistically significant differences between two groups. HLA-B27, human leukocyte antigen-B27; BASDAI, Bath ankylosing spondylitis disease activity index; BASFI, Bath ankylosing spondylitis functional index; BASMI, Bath ankylosing spondylitis metrology index; ASDAS, ankylosing spondylitis disease activity score; CRP, C-reactive protein; MRI, magnetic resonance imaging; SIJ, sacroiliac joint.

Weiß et al.

Weiß et al. Arthritis Research & Therapy 2014 16:R35   doi:10.1186/ar4464

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