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Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage

Michiel Siebelt*, Harald C Groen, Stuart J Koelewijn, Erik de Blois, Marjan Sandker, Jan H Waarsing, Cristina Müller, Gerjo JVM van Osch, Marion de Jong and Harrie Weinans

Arthritis Research & Therapy 2014, 16:R32  doi:10.1186/ar4461

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