Table 3

DAS28 (ESR) composite and individual component values, and SDAI and HAQ DI scores at 0.5, 1, 3 and 5 years of ADA exposure and last observation
Parameter 0.5 Y 1 Y 3 Y 5 Y LO
DAS28 (ESR)
 Mean (SD) 3.6 (1.5) 3.4 (1.4) 3.1 (1.3) 2.9 (1.2) 3.8 (1.6)
 Median (IQR) 3.5 (2.0) 3.3 (2.0) 2.9 (1.8) 2.8 (1.5) 3.6 (2.4)
PtGA, mm VAS
 Mean (SD) 30.6 (24.6) 27.8 (23.7) 25.1 (22.9) 23.4 (21.6) 34.5 (27.1)
 Median (IQR) 25.0 (37.0) 22.0 (35.0) 19.0 (32.0) 18.0 (30.3) 30.0 (44.0)
TJC (28)
 Mean (SD) 4.1 (5.4) 3.2 (4.6) 2.4 (4.1) 1.9 (3.6) 4.6 (6.3)
 Median (IQR) 2.0 (6.0) 2.0 (4.0) 1.0 (3.0) 0.0 (2.0) 2.0 (6.0)
SJC (28)
 Mean (SD) 3.0 (4.1) 2.3 (3.5) 1.4 (2.8) 1.1 (2.5) 3.1 (4.6)
 Median (IQR) 2.0 (4.0) 1.0 (3.0) 0.0 (2.0) 0.0 (1.0) 1.0 (4.5)
ESR, mm/h
 Mean (SD) 24.1 (20.0) 23.1 (19.3) 21.7 (17.5) 21.3 (17.3) 26.9 (22.2)
 Median (IQR) 18.0 (22.0) 18.0 (20.0) 17.0 (21.0) 17.0 (19.0) 20.0 (27.0)
SDAI
 Mean (SD) 13.7 (12.1) 11.4 (10.6) 8.8 (9.0) 7.6 (8.2) 14.7 (14.2)
 Median (IQR) 10.3 (13.5) 8.5 (11.9) 6.1 (9.3) 5.2 (8.0) 10.1 (16.8)
HAQ DI score
 Mean (SD) 1.01 (0.78) 0.94 (0.76) 0.85 (0.73) 0.80 (0.72) 1.09 (0.82)
 Median (IQR) 1.00 (1.3) 0.88 (1.3) 0.75 (1.1) 0.63 (1.1) 1.00 (1.4)

ADA, adalimumab; DAS28, 28-joint Disease Activity Score; ESR, erythrocyte sedimentation rate; HAQ DI, Health Assessment Questionnaire Disability Index; IQR, interquartile range; LO, last observation; PtGA, patient global assessment; SD, standard deviation; SDAI, Simplified Disease Activity Index; SJC, swollen joint count; TJC, tender joint count; VAS, visual analogue scale.

Burmester et al.

Burmester et al. Arthritis Research & Therapy 2014 16:R24   doi:10.1186/ar4452

Open Data