Table 2

Shared toxicities of NSAIDs

Organ system

Toxicity


Gastrointestinal

Dyspepsia

Esophagitis

Gastroduodenal ulcers

Ulcer complications (bleeding, perforation obstruction)

Small bowel erosions and strictures

Colitis

Renal

Sodium retention

Weight gain and edema

Hypertension

Type IV renal tubular acidosis and hyperkalemia

Acute renal failure

Papillary necrosis

Acute interstitial nephritis

Accelerated chronic kidney disease

Cardiovascular

Heart failure

Myocardial infarction

Stroke

Cardiovascular death

Hepatic

Elevated transaminases

Asthma/allergic

Aspirin-exacerbated respiratory diseasea (susceptible patients)

Rash

Hematologic

Cytopenias

Nervous

Dizziness, confusion, drowsiness

Seizures

Aseptic meningitis

Bone

Delayed healing


Reprinted with permission from [1]. aReduced risk in cyclooxygenase-2-selective NSAIDs

Crofford Arthritis Research & Therapy 2013 15(Suppl 3):S2   doi:10.1186/ar4174