Table 1

Potential mechanisms of resistance or of susceptibility to depletion by anti-CD20 monoclonal antibodies

Depletion

Mechanisms


B-cell and antigen related

Lack of CD20 surface expression

CD20 (antigen) modulation/endocytosis

Lipid raft composition

Expression of complement regulatory proteins

Immune host phenomena related

FcγRIIIA polymorphisms

FcγRIIB expression

C1q polymorphisms

Exhaustion of cytotoxic mechanisms (for example, complement)


Mechanisms reviewed in [24,28].

Leandro Arthritis Research & Therapy 2013 15(Suppl 1):S3   doi:10.1186/ar3908