Table 5

Adverse events reported in published studiesa during or after rituximab-induced B-cell depletion therapy

Infections

Pneumoniab

Shinglesb

Thigh abscess, subcutaneous abscess

Urinary tract infection

Septicaemia

Psuedomonas infection

Staphyloccal abscess

Streptococcal viridans infection

Necrotising fasciitis

Fatal histoplasmosis

Haematological

Neutropeniab

Pulmonary

Pneumonia

Pulmonary haemorrhage

Pulmonary embolism

Respiratory failurec

Breathlessness

Cardiac

Cardiac failurec

Fatal pancarditisc

Pericarditis

Tachycardia

Neurological

Insomnia

Transient ischaemic attack

Skin

Localised or widespread rashb

Pruritis

Urticaria

Miscellaneous

Infusion reactionsb

Serum sickness reaction

Hypogammaglobulinaemia

Anaphylaxis

Deep vein thrombosis

Dyspepsia

Malaise

Pyrexia

Polyarthralgia


aSee Table 1. bFrequently reported adverse event. cLife-threatening complications.

Reddy et al. Arthritis Research & Therapy 2013 15(Suppl 1):S2   doi:10.1186/ar3910