Table 3

Inverse-variance weighted analysis of block- 1 to -3 haplotypes
European Caucasian and low ancestry Polynesianb High ancestry Polynesianc Polynesiand All ancestriese
Hapa ORf Pf Het Pf ORf Pf Het Pf ORf Pf Het Pf ORf Pf Het Pf
(95% CI) (95% CI) (95% CI) (95% CI)
Block 1 (rs475414|rs17299124)
C|C 0.94 0.501 0.795 0.89 0.305 0.884 0.91 0.349 0.936 0.92 0.242 0.978
(0.78,1.13) (0.71,1.11) (0.74,1.11) (0.80,1.06)
T|A 1.07 0.549 0.379 0.28 6.0 × 10,4 0.512 0.50 0.006 0.120 0.56 0.103 0.007
(0.86,1.32) (0.14,0.58) (0.31,0.82) (0.28,1.12)
T|C 1.02 0.848 0.584 1.30 0.022 0.914 1.29 0.019 0.965 1.14 0.093 0.572
(0.83,1.25) (1.04,1.63) (1.04,1.56) (0.98,1.33)
Block 2 (rs693591|rs17300741|rs2078267)
C|A|C 0.97 0.800 0.726 1.24 0.070 0.128 1.20 0.083 0.219 1.10 0.253 0.179
(0.76,1.24) (0.98,1.56) (0.98,1.49) (0.93,1.30)
G|A|C 1.08 0.468 0.842 0.78 0.037 0.446 0.83 0.083 0.368 0.94 0.440 0.204
(0.88,1.31) (0.61,0.99) (0.67,1.03) (0.81,1.10)
G|G|C , , , 1.35 0.093 0.369 1.31 0.113 0.509 , , ,
(0.95,1.91) (0.94,1.83)
G|G|T 0.97 0.706 0.682 0.57 0.022 0.797 0.69 0.042 0.600 0.91 0.252 0.316
(0.81,1.15) (0.35,0.92) (0.49,0.99) (0.77,1.07)
Block 3 (rs3825018|rs475688|rs7932775|rs476037|rs478607)
A|C|T|G|A 0.82 0.040 0.953 0.76 0.035 0.272 0.77 0.024 0.451 0.80 0.004 0.594
(0.67,0.99) (0.59,0.98) (0.62,0.97) (0.68,0.93)
G|C|C|G|A 1.06 0.816 0.425 1.31g 0.105 0.969 1.23g 0.183 0.543 1.22h 0.142 0.746
(0.66,1.69) (0.95,1.81) (0.91,1.67) (0.94,1.60)
G|C|C|G|G , , , 1.33 0.116 0.702 1.29 0.151 0.752 , , ,
(0.93,1.90) (0.91,1.81)
G|T|C|G|A , , , 0.93 0.730 0.905 , , , , , ,
(0.63,1.39)
G|T|C|G|G 1.41 0.007 0.248 0.63 0.028 0.821 0.86 0.690 0.028 1.01 0.984 0.014
(1.10,1.82) (0.41,0.95) (0.41,1.80) (0.61,1.66)
G|T|T|A|A 1.01 0.947 0.731 1.19 0.573 0.029 1.07 0.590 0.062 1.06 0.579 0.118
(0.87,1.29)
(0.75,1.36) (0.66,2.14) (0.84,1.36)

aBlock 1 (rs475414|rs17299124), block 2 (rs693591|rs17300741|rs2078267), block 3. (rs3825018|rs475688|rs7932775|rs476037|rs478607) excluding frequency <0.01. bCombining the Eastern Polynesian (EP) low (EP(L)) and NZ European Caucasian sample sets. cCombining the EP high (EP(H)), Western Polynesian (WP) and EP/WP sample sets. dCombining the EP(H), EP(L), WP, and EP/WP sample sets. eCombining the EP(H), EP(L), WP, EP/WP and NZ European Caucasian sample sets. fOR: Inverse-variance weighted analysis odds ratio (adjusted for sex); P: inverse-variance weighted analysis P-value; Het P: heterogeneity P-value, inverse-variance weighted analyses were reanalyzed using a random-effects model if the Het P was <0.05. gEP/WP cohort was excluded from this meta-analysis owing to no female controls having the G|C|C|G|A haplotype.

Flynn et al.

Flynn et al. Arthritis Research & Therapy 2013 15:R220   doi:10.1186/ar4417

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