Table 2

Inverse-variance weighted analysis of allelic associations
European Caucasian and low ancestry Polynesiand High ancestry Polynesiane Polynesianf All ancestriesg
SNP Chr:Posb Effect/Otherc ORh Ph Het Ph ORh Ph Het Ph ORh Ph Het Ph ORh Ph Het Ph
(95% CI) (95% CI) (95% CI) (95% CI)
1a rs475414 11:64241844 T/C 1.02 0.862 0.990 1.15 0.233 0.727 1.12 0.270 0.839 1.07 0.376 0.861
(0.85,1.22) (0.92,1.43) (0.92,1.34) (0.93,1.23)
1 rs17299124 11:64256859 C/A 0.94 0.539 0.425 3.38 6.1 × 10,4 0.674 1.95 0.006 0.153 1.71 0.109 0.010
(0.76,1.16) (1.69,6.79) (1.21,3.15) (0.89,3.28)
2 rs693591 11:64325069 C/G 0.99 0.942 0.559 1.25 0.051 0.053 1.23 0.047 0.113 1.12 0.167 0.087
(0.78,1.26) (1.00,1.57) (1.00,1.51) (0.95,1.33)
2 rs17300741 11:64331462 A/G 1.08 0.402 0.446 1.04 0.793 0.173 1.10 0.469 0.254 1.07 0.396 0.388
(0.90,1.29) (0.78,1.38) (0.86,1.40) (0.92,1.24)
2 rs2078267 11:64334114 C/T 1.00 0.999 0.499 1.84 0.012 0.804 1.51 0.022 0.591 1.08 0.370 0.169
(0.84,1.20) (1.14,2.95) (1.06,2.14) (0.91,1.28)
3 rs3825018 11:64358809 G/A 1.24 0.028 0.660 1.33 0.020 0.568 1.34 0.008 0.767 1.27 0.002 0.822
(1.02,1.50) (1.05,1.69) (1.08,1.66) (1.10,1.48)
3 rs475688 11:64364291 T/C 1.31 0.011 0.360 0.95 0.683 0.216 1.03 0.768 0.096 1.13 0.109 0.093
(1.06,1.60) (0.76,1.20) (0.84,1.27) (0.97,1.32)
3 rs7932775 11:64367862 C/T 1.32 0.017 0.923 1.21 0.095 0.256 1.23 0.051 0.412 1.26 0.004 0.550
(1.05,1.66) (0.97,1.51) (1.00,1.51) (1.08,1.48)
3 rs476037 11:64369540 A/G 1.05 0.770 0.874 1.25 0.480 0.014 1.19 0.461 0.036 1.08 0.423 0.070
(0.78,1.40] (0.67,2.34) (0.75,1.89) (0.89,1.31)
3 rs478607 11:64478063 G/A 1.33 0.020 0.371 1.04 0.785 0.148 1.13 0.337 0.109 1.19 0.056 0.167
(1.05,1.70) (0.79,1.36) (0.88,1.44) (1.00,1.43)
4 rs12289836 11:65436888 A/G 0.87 0.156 0.435 0.89 0.327 0.717 0.91 0.423 0.791 0.88 0.085 0.863
(0.72,1.05) (0.70,1.13) (0.73,1.14) (0.76,1.02)
4 rs642803 11:65560620 T/C 0.97 0.728 0.267 0.95 0.662 0.862 1.00 0.982 0.726 0.96 0.586 0.818
(0.81,1.16) (0.76,1.19) (0.81,1.23) (0.84,1.11)

aLD block as shown in Additional file 2: Figure S1 and S2, block 1: upstream, block 2: SLC22A11, block 3: SLC22A12, block 4: downstream. bBase position is according to Genome Reference Consortium human genome build 37 (GRCh37). cEffect/Other, effect allele and other allele, all odds ratios (ORs) are calculated relevant to the effect allele defined as the allele in-phase with rs3825018 G allele according to 1,000 genomes linkage disequilibrium data. dCombining EP(L) and NZ European Caucasian sample sets. eCombining the EP(H), WP and EP/WP sample sets. fCombining the Eastern Polynesian EP high (EP(H)), EP low (EP(L)), Western Polynesian (WP) and EP/WP sample sets. gCombining the EP(H), EP(L), WP, EP/WP and NZ European Caucasian sample sets. hOR: inverse-variance weighted analysis OR (adjusted for sex); P: inverse-variance weighted analysis P-value; Het P: heterogeneity P-value, inverse-variance weighted analyses were reanalyzed using a random-effects model if the Het P was <0.05.

Flynn et al.

Flynn et al. Arthritis Research & Therapy 2013 15:R220   doi:10.1186/ar4417

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