Table 5

Change from baseline at open-label study endpoint in FIQ ‘tired upon awakening’ subscale and FOSQ
Parameter Sodium oxybate final dose
4.5 g 6 g 7.5 g 9 g Totala
FIQ subscale: ‘tired upon awakening’
Baseline, number 172 188 114 81 559
  Mean (SD) 7.93 (1.77) 8.19 (1.74) 8.35 (1.69) 8.57 (1.48) 8.21 (1.71)
Endpoint, number 168 187 114 81 554
  Mean change (SE) −4.16 (0.25) −4.56 (0.22) −3.84 (0.31) −4.88 (0.34) −4.33 (0.13)
FOSQ total score
Baseline, number 162 182 114 79 541
  Mean (SD) 14.00 (3.82) 13.73 (3.60) 13.20 (3.61) 12.76 (3.74) 13.56 (3.71)
Endpoint, number 157 181 114 79 535
  Mean change (SE) 2.75 (0.30) 3.19 (0.27) 3.28 (0.37) 3.82 (0.42) 3.15 (0.16)

Study endpoint was defined as the last available data (study completion or early discontinuation). aIf the final dose was not among those indicated, the patient was summarized only for the ‘Total’ group. FIQ, Fibromyalgia Impact Questionnaire; FOSQ, Functional Outcomes of Sleep Questionnaire; SD, standard deviation; SE, standard error.

Spaeth et al.

Spaeth et al. Arthritis Research & Therapy 2013 15:R185   doi:10.1186/ar4375

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