Mast cell-induced modulation of collagen expression by human tenocytes is mediated through prostaglandin E2. Tenocytes cultured in a three-dimensional collagen matrix were stimulated with mast cell sonicate (MCS), prostaglandin E2 (PGE2, 5 μM), or sonicate generated from indomethacin-treated mast cells (Indo MCS). Quantitative polymerase chain reaction analysis shows COL1A1transcription levels by tenocytes in response to MCS and PGE2(A), and MCS versus Indo MCS (B). *P <0.001.
Behzad et al. Arthritis Research & Therapy 2013 15:R184 doi:10.1186/ar4374