Frequencies of CD56bright and CD56dim NK cells that express the receptors NKG2D, CD94, KIRs (KIR3DL1 and KIR2DL2/2DL3) or CD16. (a-b) Peripheral blood (PB) and synovial fluid (SF) samples from four to five patients with antibiotic-responsive arthritis and four to five patients with antibiotic-refractory arthritis were analyzed for expression of NKG2D (a); CD94 (b); killer immunoglobulin-like receptors (KIRs) (c); or CD16 (d). For three of the five responsive patients, PB and SF samples were matched, and all PB and SF samples from refractory patients were matched. Symbols indicate individual subjects, horizontal bars represent the median of each group and significant differences are denoted. Statistical analyses were performed by using the Mann-Whitney test.
Katchar et al. Arthritis Research & Therapy 2013 15:R183 doi:10.1186/ar4373